Pre-emptive analgesia with the combination of tramadol plus meloxicam for third molar surgery: A pilot study

Mario Alberto Isiordia-Espinoza, Martín Sánchez-Prieto, Francisco Tobías-Azúa, Juan Gerardo Reyes-García, Vinicio Granados Soto

Resultado de la investigación: Contribución a una revistaArtículo

10 Citas (Scopus)

Resumen

The aim of this pilot study was to evaluate pre-emptive analgesia using the combination tramadol plus meloxicam compared with each individual drug alone for the reduction of pain after extraction of third molars. Fifty-one patients were randomised into three groups (n = 17 in each), using a series of random numbers: the first group was given tramadol 25 mg and meloxicam 7.5 mg; the second tramadol 50 mg, and the third meloxicam 15 mg, all intramuscularly. Treatments were prepared in identical syringes by an independent investigator and were given immediately. The teeth were removed 50 min after the analgesics had been given. Intensity of pain, consumption of analgesics, and adverse effects were evaluated. The intensity of pain was evaluated using a visual analogue scale (VAS) and the area under the curve of the VAS showed significant differences amongst the groups. In conclusion, the study showed that the combination of tramadol 25 mg and meloxicam 7.5 mg had an analgesic effect similar to that of meloxicam 15 mg, but both were better than tramadol 50 mg for relief of pain after the extraction of mandibular third molars.

Idioma originalInglés
Páginas (desde-hasta)673-677
Número de páginas5
PublicaciónBritish Journal of Oral and Maxillofacial Surgery
Volumen50
N.º7
DOI
EstadoPublicada - 1 oct 2012

Huella dactilar

meloxicam
Tramadol
Third Molar
Analgesia
Analgesics
Pain
Visual Analog Scale
Syringes
Area Under Curve
Tooth
Research Personnel

Citar esto

Isiordia-Espinoza, Mario Alberto ; Sánchez-Prieto, Martín ; Tobías-Azúa, Francisco ; Reyes-García, Juan Gerardo ; Granados Soto, Vinicio. / Pre-emptive analgesia with the combination of tramadol plus meloxicam for third molar surgery : A pilot study. En: British Journal of Oral and Maxillofacial Surgery. 2012 ; Vol. 50, N.º 7. pp. 673-677.
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abstract = "The aim of this pilot study was to evaluate pre-emptive analgesia using the combination tramadol plus meloxicam compared with each individual drug alone for the reduction of pain after extraction of third molars. Fifty-one patients were randomised into three groups (n = 17 in each), using a series of random numbers: the first group was given tramadol 25 mg and meloxicam 7.5 mg; the second tramadol 50 mg, and the third meloxicam 15 mg, all intramuscularly. Treatments were prepared in identical syringes by an independent investigator and were given immediately. The teeth were removed 50 min after the analgesics had been given. Intensity of pain, consumption of analgesics, and adverse effects were evaluated. The intensity of pain was evaluated using a visual analogue scale (VAS) and the area under the curve of the VAS showed significant differences amongst the groups. In conclusion, the study showed that the combination of tramadol 25 mg and meloxicam 7.5 mg had an analgesic effect similar to that of meloxicam 15 mg, but both were better than tramadol 50 mg for relief of pain after the extraction of mandibular third molars.",
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Pre-emptive analgesia with the combination of tramadol plus meloxicam for third molar surgery : A pilot study. / Isiordia-Espinoza, Mario Alberto; Sánchez-Prieto, Martín; Tobías-Azúa, Francisco; Reyes-García, Juan Gerardo; Granados Soto, Vinicio.

En: British Journal of Oral and Maxillofacial Surgery, Vol. 50, N.º 7, 01.10.2012, p. 673-677.

Resultado de la investigación: Contribución a una revistaArtículo

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AU - Isiordia-Espinoza, Mario Alberto

AU - Sánchez-Prieto, Martín

AU - Tobías-Azúa, Francisco

AU - Reyes-García, Juan Gerardo

AU - Granados Soto, Vinicio

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N2 - The aim of this pilot study was to evaluate pre-emptive analgesia using the combination tramadol plus meloxicam compared with each individual drug alone for the reduction of pain after extraction of third molars. Fifty-one patients were randomised into three groups (n = 17 in each), using a series of random numbers: the first group was given tramadol 25 mg and meloxicam 7.5 mg; the second tramadol 50 mg, and the third meloxicam 15 mg, all intramuscularly. Treatments were prepared in identical syringes by an independent investigator and were given immediately. The teeth were removed 50 min after the analgesics had been given. Intensity of pain, consumption of analgesics, and adverse effects were evaluated. The intensity of pain was evaluated using a visual analogue scale (VAS) and the area under the curve of the VAS showed significant differences amongst the groups. In conclusion, the study showed that the combination of tramadol 25 mg and meloxicam 7.5 mg had an analgesic effect similar to that of meloxicam 15 mg, but both were better than tramadol 50 mg for relief of pain after the extraction of mandibular third molars.

AB - The aim of this pilot study was to evaluate pre-emptive analgesia using the combination tramadol plus meloxicam compared with each individual drug alone for the reduction of pain after extraction of third molars. Fifty-one patients were randomised into three groups (n = 17 in each), using a series of random numbers: the first group was given tramadol 25 mg and meloxicam 7.5 mg; the second tramadol 50 mg, and the third meloxicam 15 mg, all intramuscularly. Treatments were prepared in identical syringes by an independent investigator and were given immediately. The teeth were removed 50 min after the analgesics had been given. Intensity of pain, consumption of analgesics, and adverse effects were evaluated. The intensity of pain was evaluated using a visual analogue scale (VAS) and the area under the curve of the VAS showed significant differences amongst the groups. In conclusion, the study showed that the combination of tramadol 25 mg and meloxicam 7.5 mg had an analgesic effect similar to that of meloxicam 15 mg, but both were better than tramadol 50 mg for relief of pain after the extraction of mandibular third molars.

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