Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features

Adriana Cambón, Silvia Barbosa, Ana Rey-Rico, Edgar B. Figueroa-Ochoa, J. Felix armando Soltero Martinez, Steven G. Yeates, Carmen Alvarez-Lorenzo, Angel Concheiro, Pablo Taboada, Víctor Mosquera

Resultado de la investigación: Contribución a una revistaArtículo

14 Citas (Scopus)

Resumen

Two new poly(ethylene oxide)-poly(styrene oxide) triblock copolymers (PEO-PSO-PEO) with optimized block lengths selected on the basis of previous studies were synthesized with the aim of achieving a maximal solubilization ability and a suitable sustained release, while keeping very low material expense and excellent aqueous copolymer solubility. The self-assembling and gelling properties of these copolymers were characterized by means of light scattering, fluorescence spectroscopy, transmission electron microscopy, and rheometry. Both copolymers formed spherical micelles (12-14nm) at very low concentrations. At larger concentration (>25wt%), copolymer solutions showed a rich phase behavior, with the appearance of two types of rheologically active (more viscous) fluids and of physical gels depending on solution temperature and concentration. The copolymer behaved notably different despite their relatively similar block lengths. The ability of the polymeric micellar solutions to solubilize the antifungal drug griseofulvin was evaluated and compared to that reported for other structurally-related block copolymers. Drug solubilization values up to 55mgg-1 were achieved, which are greater than those obtained by previously analyzed poly(ethylene oxide)-poly(styrene oxide), poly(ethylene oxide)-poly(butylene oxide), and poly(ethylene oxide)-poly(propylene oxide) block copolymers. The results indicate that the selected SO/EO ratio and copolymer block lengths were optimal for simultaneously achieving low critical micelle concentrations (cmc) values and large drug encapsulation ability. The amount of drug released from the polymeric micelles was larger at pH 7.4 than at acidic conditions, although still sustained over 1day.

Idioma originalInglés
Páginas (desde-hasta)275-284
Número de páginas10
PublicaciónJournal of Colloid And Interface Science
Volumen387
N.º1
DOI
EstadoPublicada - 1 dic 2012

Huella dactilar

styrene oxide
Micellization
Polyethylene oxides
Styrene
Copolymers
Block copolymers
Oxides
Pharmaceutical Preparations
Micelles
Griseofulvin
Critical micelle concentration
Fluorescence spectroscopy
Polypropylene oxides
Phase behavior
Encapsulation
Light scattering
Particle swarm optimization (PSO)
Solubility
Gels
Transmission electron microscopy

Citar esto

Cambón, Adriana ; Barbosa, Silvia ; Rey-Rico, Ana ; Figueroa-Ochoa, Edgar B. ; Soltero Martinez, J. Felix armando ; Yeates, Steven G. ; Alvarez-Lorenzo, Carmen ; Concheiro, Angel ; Taboada, Pablo ; Mosquera, Víctor. / Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers : Micellization, drug solubilization, and gelling features. En: Journal of Colloid And Interface Science. 2012 ; Vol. 387, N.º 1. pp. 275-284.
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title = "Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features",
abstract = "Two new poly(ethylene oxide)-poly(styrene oxide) triblock copolymers (PEO-PSO-PEO) with optimized block lengths selected on the basis of previous studies were synthesized with the aim of achieving a maximal solubilization ability and a suitable sustained release, while keeping very low material expense and excellent aqueous copolymer solubility. The self-assembling and gelling properties of these copolymers were characterized by means of light scattering, fluorescence spectroscopy, transmission electron microscopy, and rheometry. Both copolymers formed spherical micelles (12-14nm) at very low concentrations. At larger concentration (>25wt{\%}), copolymer solutions showed a rich phase behavior, with the appearance of two types of rheologically active (more viscous) fluids and of physical gels depending on solution temperature and concentration. The copolymer behaved notably different despite their relatively similar block lengths. The ability of the polymeric micellar solutions to solubilize the antifungal drug griseofulvin was evaluated and compared to that reported for other structurally-related block copolymers. Drug solubilization values up to 55mgg-1 were achieved, which are greater than those obtained by previously analyzed poly(ethylene oxide)-poly(styrene oxide), poly(ethylene oxide)-poly(butylene oxide), and poly(ethylene oxide)-poly(propylene oxide) block copolymers. The results indicate that the selected SO/EO ratio and copolymer block lengths were optimal for simultaneously achieving low critical micelle concentrations (cmc) values and large drug encapsulation ability. The amount of drug released from the polymeric micelles was larger at pH 7.4 than at acidic conditions, although still sustained over 1day.",
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author = "Adriana Camb{\'o}n and Silvia Barbosa and Ana Rey-Rico and Figueroa-Ochoa, {Edgar B.} and {Soltero Martinez}, {J. Felix armando} and Yeates, {Steven G.} and Carmen Alvarez-Lorenzo and Angel Concheiro and Pablo Taboada and V{\'i}ctor Mosquera",
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Cambón, A, Barbosa, S, Rey-Rico, A, Figueroa-Ochoa, EB, Soltero Martinez, JFA, Yeates, SG, Alvarez-Lorenzo, C, Concheiro, A, Taboada, P & Mosquera, V 2012, 'Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features', Journal of Colloid And Interface Science, vol. 387, n.º 1, pp. 275-284. https://doi.org/10.1016/j.jcis.2012.06.090

Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers : Micellization, drug solubilization, and gelling features. / Cambón, Adriana; Barbosa, Silvia; Rey-Rico, Ana; Figueroa-Ochoa, Edgar B.; Soltero Martinez, J. Felix armando; Yeates, Steven G.; Alvarez-Lorenzo, Carmen; Concheiro, Angel; Taboada, Pablo; Mosquera, Víctor.

En: Journal of Colloid And Interface Science, Vol. 387, N.º 1, 01.12.2012, p. 275-284.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Poly(ethylene oxide)-poly(styrene oxide)-poly(ethylene oxide) copolymers

T2 - Micellization, drug solubilization, and gelling features

AU - Cambón, Adriana

AU - Barbosa, Silvia

AU - Rey-Rico, Ana

AU - Figueroa-Ochoa, Edgar B.

AU - Soltero Martinez, J. Felix armando

AU - Yeates, Steven G.

AU - Alvarez-Lorenzo, Carmen

AU - Concheiro, Angel

AU - Taboada, Pablo

AU - Mosquera, Víctor

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Two new poly(ethylene oxide)-poly(styrene oxide) triblock copolymers (PEO-PSO-PEO) with optimized block lengths selected on the basis of previous studies were synthesized with the aim of achieving a maximal solubilization ability and a suitable sustained release, while keeping very low material expense and excellent aqueous copolymer solubility. The self-assembling and gelling properties of these copolymers were characterized by means of light scattering, fluorescence spectroscopy, transmission electron microscopy, and rheometry. Both copolymers formed spherical micelles (12-14nm) at very low concentrations. At larger concentration (>25wt%), copolymer solutions showed a rich phase behavior, with the appearance of two types of rheologically active (more viscous) fluids and of physical gels depending on solution temperature and concentration. The copolymer behaved notably different despite their relatively similar block lengths. The ability of the polymeric micellar solutions to solubilize the antifungal drug griseofulvin was evaluated and compared to that reported for other structurally-related block copolymers. Drug solubilization values up to 55mgg-1 were achieved, which are greater than those obtained by previously analyzed poly(ethylene oxide)-poly(styrene oxide), poly(ethylene oxide)-poly(butylene oxide), and poly(ethylene oxide)-poly(propylene oxide) block copolymers. The results indicate that the selected SO/EO ratio and copolymer block lengths were optimal for simultaneously achieving low critical micelle concentrations (cmc) values and large drug encapsulation ability. The amount of drug released from the polymeric micelles was larger at pH 7.4 than at acidic conditions, although still sustained over 1day.

AB - Two new poly(ethylene oxide)-poly(styrene oxide) triblock copolymers (PEO-PSO-PEO) with optimized block lengths selected on the basis of previous studies were synthesized with the aim of achieving a maximal solubilization ability and a suitable sustained release, while keeping very low material expense and excellent aqueous copolymer solubility. The self-assembling and gelling properties of these copolymers were characterized by means of light scattering, fluorescence spectroscopy, transmission electron microscopy, and rheometry. Both copolymers formed spherical micelles (12-14nm) at very low concentrations. At larger concentration (>25wt%), copolymer solutions showed a rich phase behavior, with the appearance of two types of rheologically active (more viscous) fluids and of physical gels depending on solution temperature and concentration. The copolymer behaved notably different despite their relatively similar block lengths. The ability of the polymeric micellar solutions to solubilize the antifungal drug griseofulvin was evaluated and compared to that reported for other structurally-related block copolymers. Drug solubilization values up to 55mgg-1 were achieved, which are greater than those obtained by previously analyzed poly(ethylene oxide)-poly(styrene oxide), poly(ethylene oxide)-poly(butylene oxide), and poly(ethylene oxide)-poly(propylene oxide) block copolymers. The results indicate that the selected SO/EO ratio and copolymer block lengths were optimal for simultaneously achieving low critical micelle concentrations (cmc) values and large drug encapsulation ability. The amount of drug released from the polymeric micelles was larger at pH 7.4 than at acidic conditions, although still sustained over 1day.

KW - Block copolymer

KW - Drug delivery system

KW - Phase behavior

KW - Polymeric micelle

KW - Release kinetics

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U2 - 10.1016/j.jcis.2012.06.090

DO - 10.1016/j.jcis.2012.06.090

M3 - Artículo

C2 - 22939527

AN - SCOPUS:84866630016

VL - 387

SP - 275

EP - 284

JO - Journal of Colloid And Interface Science

JF - Journal of Colloid And Interface Science

SN - 0021-9797

IS - 1

ER -