Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico

Gamola Z. Fortenberry, John D. Meeker, Brisa N. Sánchez, David Bellinger, Karen Peterson, Lourdes Schnaas, Maritsa Solano-González, Adrienne S. Ettinger, Mauricio Hernandez Avila, Howard Hu, Martha Maria Tellez Rojo solis

Resultado de la investigación: Contribución a una revistaArtículo

5 Citas (Scopus)

Resumen

Globally, organophosphate (OP) pesticide usage and exposure is widespread. Studies have found that fetuses and infants are more sensitive than adults to environmental toxicants and that prenatal exposure to low levels of OPs has been associated with Attention Deficit Hyperactivity Disorder-Like Phenotypes (ADHD-LP). Paraoxonase 1 (PON1) is an enzyme involved in detoxifying some OPs and its polymorphisms influence enzyme activity and quantity. The objective of this study was to examine whether maternal and/or child PON1 genotypes (PON1R192Q and PON1L55M) were associated with ADHD-LP in a Mexico City, Mexico birth cohort. PON1R192Q and PON1L55M genotypes in mothers (PON1R192Q: N=531; PON1L55M: N=458) and children (PON1R192Q: N=532; PON1L55M: N=478) from blood DNA were determined. We assessed ADHD-LP for children between the ages of 6 and 13 using Conners[U+05F3] Parent Rating Scales-Revised (CRS-R), Conners[U+05F3] Continuous Performance Test (CPT), and the parent scores for Behavior Assessment System for Children-2 (BASC2). Multivariable linear regression models were used to test relationships between ADHD-LP and PON1 polymorphisms. In these models, significant associations were observed with maternal genotypes but not with the child genotypes. A higher DSM IV Hyperactivity/Impulsivity score (β=3.27 points; 95% CI (0.89, 5.65)) and a 2.17 higher score in child DSM IV Total (95% CI (0.05, 4.29)) were observed for maternal PON155MM in comparison to PON155LM+LL. The childattention problems score was 2.27 points higher (95% CI (0.002, 4.53) for maternal PON1192QQ in comparison to PON1192QR+RR. Because maternal PON1 polymorphisms were associated with child ADHD-LP, this may be a viable biomarker of susceptibility for ADHD-LP.

Idioma originalInglés
Páginas (desde-hasta)342-349
Número de páginas8
PublicaciónEnvironmental Research
Volumen132
DOI
EstadoPublicada - 1 ene 2014

Huella dactilar

Aryldialkylphosphatase
Mexico
Polymorphism
Attention Deficit Disorder with Hyperactivity
polymorphism
phenotype
Mothers
Phenotype
genotype
Genotype
Organophosphates
Diagnostic and Statistical Manual of Mental Disorders
Enzyme activity
Biomarkers
Pesticides
Linear regression
Linear Models
Blood
Impulsive Behavior
Enzymes

Citar esto

Fortenberry, Gamola Z. ; Meeker, John D. ; Sánchez, Brisa N. ; Bellinger, David ; Peterson, Karen ; Schnaas, Lourdes ; Solano-González, Maritsa ; Ettinger, Adrienne S. ; Hernandez Avila, Mauricio ; Hu, Howard ; Tellez Rojo solis, Martha Maria. / Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico. En: Environmental Research. 2014 ; Vol. 132. pp. 342-349.
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title = "Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico",
abstract = "Globally, organophosphate (OP) pesticide usage and exposure is widespread. Studies have found that fetuses and infants are more sensitive than adults to environmental toxicants and that prenatal exposure to low levels of OPs has been associated with Attention Deficit Hyperactivity Disorder-Like Phenotypes (ADHD-LP). Paraoxonase 1 (PON1) is an enzyme involved in detoxifying some OPs and its polymorphisms influence enzyme activity and quantity. The objective of this study was to examine whether maternal and/or child PON1 genotypes (PON1R192Q and PON1L55M) were associated with ADHD-LP in a Mexico City, Mexico birth cohort. PON1R192Q and PON1L55M genotypes in mothers (PON1R192Q: N=531; PON1L55M: N=458) and children (PON1R192Q: N=532; PON1L55M: N=478) from blood DNA were determined. We assessed ADHD-LP for children between the ages of 6 and 13 using Conners[U+05F3] Parent Rating Scales-Revised (CRS-R), Conners[U+05F3] Continuous Performance Test (CPT), and the parent scores for Behavior Assessment System for Children-2 (BASC2). Multivariable linear regression models were used to test relationships between ADHD-LP and PON1 polymorphisms. In these models, significant associations were observed with maternal genotypes but not with the child genotypes. A higher DSM IV Hyperactivity/Impulsivity score (β=3.27 points; 95{\%} CI (0.89, 5.65)) and a 2.17 higher score in child DSM IV Total (95{\%} CI (0.05, 4.29)) were observed for maternal PON155MM in comparison to PON155LM+LL. The childattention problems score was 2.27 points higher (95{\%} CI (0.002, 4.53) for maternal PON1192QQ in comparison to PON1192QR+RR. Because maternal PON1 polymorphisms were associated with child ADHD-LP, this may be a viable biomarker of susceptibility for ADHD-LP.",
keywords = "ADHD, Biomarker, Exposure, Human, Paraoxonase 1 polymorphisms",
author = "Fortenberry, {Gamola Z.} and Meeker, {John D.} and S{\'a}nchez, {Brisa N.} and David Bellinger and Karen Peterson and Lourdes Schnaas and Maritsa Solano-Gonz{\'a}lez and Ettinger, {Adrienne S.} and {Hernandez Avila}, Mauricio and Howard Hu and {Tellez Rojo solis}, {Martha Maria}",
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Fortenberry, GZ, Meeker, JD, Sánchez, BN, Bellinger, D, Peterson, K, Schnaas, L, Solano-González, M, Ettinger, AS, Hernandez Avila, M, Hu, H & Tellez Rojo solis, MM 2014, 'Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico', Environmental Research, vol. 132, pp. 342-349. https://doi.org/10.1016/j.envres.2014.04.010

Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico. / Fortenberry, Gamola Z.; Meeker, John D.; Sánchez, Brisa N.; Bellinger, David; Peterson, Karen; Schnaas, Lourdes; Solano-González, Maritsa; Ettinger, Adrienne S.; Hernandez Avila, Mauricio; Hu, Howard; Tellez Rojo solis, Martha Maria.

En: Environmental Research, Vol. 132, 01.01.2014, p. 342-349.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Paraoxonase I polymorphisms and attention/hyperactivity in school-age children from Mexico City, Mexico

AU - Fortenberry, Gamola Z.

AU - Meeker, John D.

AU - Sánchez, Brisa N.

AU - Bellinger, David

AU - Peterson, Karen

AU - Schnaas, Lourdes

AU - Solano-González, Maritsa

AU - Ettinger, Adrienne S.

AU - Hernandez Avila, Mauricio

AU - Hu, Howard

AU - Tellez Rojo solis, Martha Maria

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Globally, organophosphate (OP) pesticide usage and exposure is widespread. Studies have found that fetuses and infants are more sensitive than adults to environmental toxicants and that prenatal exposure to low levels of OPs has been associated with Attention Deficit Hyperactivity Disorder-Like Phenotypes (ADHD-LP). Paraoxonase 1 (PON1) is an enzyme involved in detoxifying some OPs and its polymorphisms influence enzyme activity and quantity. The objective of this study was to examine whether maternal and/or child PON1 genotypes (PON1R192Q and PON1L55M) were associated with ADHD-LP in a Mexico City, Mexico birth cohort. PON1R192Q and PON1L55M genotypes in mothers (PON1R192Q: N=531; PON1L55M: N=458) and children (PON1R192Q: N=532; PON1L55M: N=478) from blood DNA were determined. We assessed ADHD-LP for children between the ages of 6 and 13 using Conners[U+05F3] Parent Rating Scales-Revised (CRS-R), Conners[U+05F3] Continuous Performance Test (CPT), and the parent scores for Behavior Assessment System for Children-2 (BASC2). Multivariable linear regression models were used to test relationships between ADHD-LP and PON1 polymorphisms. In these models, significant associations were observed with maternal genotypes but not with the child genotypes. A higher DSM IV Hyperactivity/Impulsivity score (β=3.27 points; 95% CI (0.89, 5.65)) and a 2.17 higher score in child DSM IV Total (95% CI (0.05, 4.29)) were observed for maternal PON155MM in comparison to PON155LM+LL. The childattention problems score was 2.27 points higher (95% CI (0.002, 4.53) for maternal PON1192QQ in comparison to PON1192QR+RR. Because maternal PON1 polymorphisms were associated with child ADHD-LP, this may be a viable biomarker of susceptibility for ADHD-LP.

AB - Globally, organophosphate (OP) pesticide usage and exposure is widespread. Studies have found that fetuses and infants are more sensitive than adults to environmental toxicants and that prenatal exposure to low levels of OPs has been associated with Attention Deficit Hyperactivity Disorder-Like Phenotypes (ADHD-LP). Paraoxonase 1 (PON1) is an enzyme involved in detoxifying some OPs and its polymorphisms influence enzyme activity and quantity. The objective of this study was to examine whether maternal and/or child PON1 genotypes (PON1R192Q and PON1L55M) were associated with ADHD-LP in a Mexico City, Mexico birth cohort. PON1R192Q and PON1L55M genotypes in mothers (PON1R192Q: N=531; PON1L55M: N=458) and children (PON1R192Q: N=532; PON1L55M: N=478) from blood DNA were determined. We assessed ADHD-LP for children between the ages of 6 and 13 using Conners[U+05F3] Parent Rating Scales-Revised (CRS-R), Conners[U+05F3] Continuous Performance Test (CPT), and the parent scores for Behavior Assessment System for Children-2 (BASC2). Multivariable linear regression models were used to test relationships between ADHD-LP and PON1 polymorphisms. In these models, significant associations were observed with maternal genotypes but not with the child genotypes. A higher DSM IV Hyperactivity/Impulsivity score (β=3.27 points; 95% CI (0.89, 5.65)) and a 2.17 higher score in child DSM IV Total (95% CI (0.05, 4.29)) were observed for maternal PON155MM in comparison to PON155LM+LL. The childattention problems score was 2.27 points higher (95% CI (0.002, 4.53) for maternal PON1192QQ in comparison to PON1192QR+RR. Because maternal PON1 polymorphisms were associated with child ADHD-LP, this may be a viable biomarker of susceptibility for ADHD-LP.

KW - ADHD

KW - Biomarker

KW - Exposure

KW - Human

KW - Paraoxonase 1 polymorphisms

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U2 - 10.1016/j.envres.2014.04.010

DO - 10.1016/j.envres.2014.04.010

M3 - Artículo

C2 - 24834831

AN - SCOPUS:84900385682

VL - 132

SP - 342

EP - 349

JO - Environmental Research

JF - Environmental Research

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