Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study

Jaime Berumen Campos, Lorena Orozco, Miguel Betancourt-Cravioto, Héctor Gallardo, Mirella Zulueta, Leire Mendizabal, Laureano Simon, Rosa Elba Benuto, Elisa Ramírez-Campos, Melissa Marin, Eligia Juárez, Humberto García-Ortiz, Angélica Martínez-Hernández, Carlos Venegas-Vega, Jesús Peralta-Romero, Miguel Cruz, Robert Constantino Tapia Conyer

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence of each factor on T2D variability is unclear. This study aimed to investigate the influence of obesity (body mass index [BMI], waist/hip ratio), PH, and 16 single-nucleotide polymorphisms (SNPs) associated with T2D on T2D variability in Mexico, comparing 1234 non-diabetic controls and 1219 diabetic patients. To replicate the data, a case-control (n = 2904) and a cross-sectional (n = 1901) study were also included. In a multivariate logistic regression model, all factors accounted for only 27.3% of T2D variability: SNPs (8.4%); PH (11.8%) and obesity (7.1%). These factors contributed more in men (33.2%) than in women (25%), specifically when the disease was diagnosed before the age of 46 (46.7% vs. 30%). Genes played a substantially more important role in men than in women (14.9% vs. 5.5%), while obesity and PH played a similar role in both genders. Genes and PH appeared to play a greater role than obesity in T2D. However, obesity contribution was calculated at the time of recruitment and may be underestimated in patients because the BMI decreased linearly with the number of years with the disease. The data suggest that sexual hormones may play important roles in genes that are associated with T2D.

Idioma originalInglés
Número de artículo2748
PublicaciónScientific Reports
Volumen9
N.º1
DOI
EstadoPublicada - 1 dic 2019

Huella dactilar

Type 2 Diabetes Mellitus
Case-Control Studies
Obesity
Genes
Single Nucleotide Polymorphism
Body Mass Index
Logistic Models
Waist-Hip Ratio
Mexico
Hormones

Citar esto

Berumen Campos, Jaime ; Orozco, Lorena ; Betancourt-Cravioto, Miguel ; Gallardo, Héctor ; Zulueta, Mirella ; Mendizabal, Leire ; Simon, Laureano ; Benuto, Rosa Elba ; Ramírez-Campos, Elisa ; Marin, Melissa ; Juárez, Eligia ; García-Ortiz, Humberto ; Martínez-Hernández, Angélica ; Venegas-Vega, Carlos ; Peralta-Romero, Jesús ; Cruz, Miguel ; Tapia Conyer, Robert Constantino. / Influence of obesity, parental history of diabetes, and genes in type 2 diabetes : A case-control study. En: Scientific Reports. 2019 ; Vol. 9, N.º 1.
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title = "Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study",
abstract = "Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence of each factor on T2D variability is unclear. This study aimed to investigate the influence of obesity (body mass index [BMI], waist/hip ratio), PH, and 16 single-nucleotide polymorphisms (SNPs) associated with T2D on T2D variability in Mexico, comparing 1234 non-diabetic controls and 1219 diabetic patients. To replicate the data, a case-control (n = 2904) and a cross-sectional (n = 1901) study were also included. In a multivariate logistic regression model, all factors accounted for only 27.3{\%} of T2D variability: SNPs (8.4{\%}); PH (11.8{\%}) and obesity (7.1{\%}). These factors contributed more in men (33.2{\%}) than in women (25{\%}), specifically when the disease was diagnosed before the age of 46 (46.7{\%} vs. 30{\%}). Genes played a substantially more important role in men than in women (14.9{\%} vs. 5.5{\%}), while obesity and PH played a similar role in both genders. Genes and PH appeared to play a greater role than obesity in T2D. However, obesity contribution was calculated at the time of recruitment and may be underestimated in patients because the BMI decreased linearly with the number of years with the disease. The data suggest that sexual hormones may play important roles in genes that are associated with T2D.",
author = "{Berumen Campos}, Jaime and Lorena Orozco and Miguel Betancourt-Cravioto and H{\'e}ctor Gallardo and Mirella Zulueta and Leire Mendizabal and Laureano Simon and Benuto, {Rosa Elba} and Elisa Ram{\'i}rez-Campos and Melissa Marin and Eligia Ju{\'a}rez and Humberto Garc{\'i}a-Ortiz and Ang{\'e}lica Mart{\'i}nez-Hern{\'a}ndez and Carlos Venegas-Vega and Jes{\'u}s Peralta-Romero and Miguel Cruz and {Tapia Conyer}, {Robert Constantino}",
year = "2019",
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Berumen Campos, J, Orozco, L, Betancourt-Cravioto, M, Gallardo, H, Zulueta, M, Mendizabal, L, Simon, L, Benuto, RE, Ramírez-Campos, E, Marin, M, Juárez, E, García-Ortiz, H, Martínez-Hernández, A, Venegas-Vega, C, Peralta-Romero, J, Cruz, M & Tapia Conyer, RC 2019, 'Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study', Scientific Reports, vol. 9, n.º 1, 2748. https://doi.org/10.1038/s41598-019-39145-x

Influence of obesity, parental history of diabetes, and genes in type 2 diabetes : A case-control study. / Berumen Campos, Jaime; Orozco, Lorena; Betancourt-Cravioto, Miguel; Gallardo, Héctor; Zulueta, Mirella; Mendizabal, Leire; Simon, Laureano; Benuto, Rosa Elba; Ramírez-Campos, Elisa; Marin, Melissa; Juárez, Eligia; García-Ortiz, Humberto; Martínez-Hernández, Angélica; Venegas-Vega, Carlos; Peralta-Romero, Jesús; Cruz, Miguel; Tapia Conyer, Robert Constantino.

En: Scientific Reports, Vol. 9, N.º 1, 2748, 01.12.2019.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Influence of obesity, parental history of diabetes, and genes in type 2 diabetes

T2 - A case-control study

AU - Berumen Campos, Jaime

AU - Orozco, Lorena

AU - Betancourt-Cravioto, Miguel

AU - Gallardo, Héctor

AU - Zulueta, Mirella

AU - Mendizabal, Leire

AU - Simon, Laureano

AU - Benuto, Rosa Elba

AU - Ramírez-Campos, Elisa

AU - Marin, Melissa

AU - Juárez, Eligia

AU - García-Ortiz, Humberto

AU - Martínez-Hernández, Angélica

AU - Venegas-Vega, Carlos

AU - Peralta-Romero, Jesús

AU - Cruz, Miguel

AU - Tapia Conyer, Robert Constantino

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Obesity, parental history (PH) of type 2 diabetes (T2D), and genes play an important role in T2D development. However, the influence of each factor on T2D variability is unclear. This study aimed to investigate the influence of obesity (body mass index [BMI], waist/hip ratio), PH, and 16 single-nucleotide polymorphisms (SNPs) associated with T2D on T2D variability in Mexico, comparing 1234 non-diabetic controls and 1219 diabetic patients. To replicate the data, a case-control (n = 2904) and a cross-sectional (n = 1901) study were also included. In a multivariate logistic regression model, all factors accounted for only 27.3% of T2D variability: SNPs (8.4%); PH (11.8%) and obesity (7.1%). These factors contributed more in men (33.2%) than in women (25%), specifically when the disease was diagnosed before the age of 46 (46.7% vs. 30%). Genes played a substantially more important role in men than in women (14.9% vs. 5.5%), while obesity and PH played a similar role in both genders. Genes and PH appeared to play a greater role than obesity in T2D. However, obesity contribution was calculated at the time of recruitment and may be underestimated in patients because the BMI decreased linearly with the number of years with the disease. The data suggest that sexual hormones may play important roles in genes that are associated with T2D.

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DO - 10.1038/s41598-019-39145-x

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