Improvement of learned behavior through cholinergic stimulation of the caudate nucleus

R. A. Prado-Alcalà, G. G. Cobos-Zapiaín

Resultado de la investigación: Contribución a una revistaArtículo

22 Citas (Scopus)

Resumen

To test the hypothesis that cholinergic activity of the head of the caudate nucleus (CN) is involved in the processes underlying instrumental performance, the effects of microinjections of several doses of choline into this structure on lever pressing behavior were assessed. A dose-dependent modification of performance was found: small doses improve and large doses impair level pressing, while choline applications into the parietal cortex were without effect. The facilitatory effects were reproduced by microinjections of acetylcholine into the CN. These data further support our working hypothesis.

Idioma originalInglés
Páginas (desde-hasta)253-258
Número de páginas6
PublicaciónNeuroscience Letters
Volumen14
N.º2-3
DOI
EstadoPublicada - oct 1979

Huella dactilar

Caudate Nucleus
Microinjections
Choline
Cholinergic Agents
Parietal Lobe
Acetylcholine

Citar esto

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Improvement of learned behavior through cholinergic stimulation of the caudate nucleus. / Prado-Alcalà, R. A.; Cobos-Zapiaín, G. G.

En: Neuroscience Letters, Vol. 14, N.º 2-3, 10.1979, p. 253-258.

Resultado de la investigación: Contribución a una revistaArtículo

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AU - Cobos-Zapiaín, G. G.

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N2 - To test the hypothesis that cholinergic activity of the head of the caudate nucleus (CN) is involved in the processes underlying instrumental performance, the effects of microinjections of several doses of choline into this structure on lever pressing behavior were assessed. A dose-dependent modification of performance was found: small doses improve and large doses impair level pressing, while choline applications into the parietal cortex were without effect. The facilitatory effects were reproduced by microinjections of acetylcholine into the CN. These data further support our working hypothesis.

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