Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico

Ronna Delgado-Altamirano, Rosa Isela López-Palma, Lianet Monzote, José Delgado-Domínguez, Ingeborg Becker, José Fausto Rivero-Cruz, Nuria Esturau-Escofet, Pedro A. Vázquez-Landaverde, Alejandra Rojas-Molina

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC 50 ) = 12.02 ± 0.36 µM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

Idioma originalInglés
Número de artículo872
PublicaciónInternational journal of molecular sciences
Volumen20
N.º4
DOI
EstadoPublicada - 2 feb 2019

Huella dactilar

Lantana
Leishmaniasis
Mexico
Leishmania mexicana
Norisoprenoids
Lead compounds
Squalene
acids
Acids
Bioassay
Drug Design
Leishmania
Methylene Chloride
Fractionation
Biological Products
Biological Assay
Inhibitory Concentration 50
lead compounds
bioassay
Dichloromethane

Citar esto

Delgado-Altamirano, Ronna ; López-Palma, Rosa Isela ; Monzote, Lianet ; Delgado-Domínguez, José ; Becker, Ingeborg ; Rivero-Cruz, José Fausto ; Esturau-Escofet, Nuria ; Vázquez-Landaverde, Pedro A. ; Rojas-Molina, Alejandra. / Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico. En: International journal of molecular sciences. 2019 ; Vol. 20, N.º 4.
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title = "Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico",
abstract = "Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79{\%}/21{\%}) was the most potent one (half maximal inhibitory concentration (IC 50 ) = 12.02 ± 0.36 µM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.",
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author = "Ronna Delgado-Altamirano and L{\'o}pez-Palma, {Rosa Isela} and Lianet Monzote and Jos{\'e} Delgado-Dom{\'i}nguez and Ingeborg Becker and Rivero-Cruz, {Jos{\'e} Fausto} and Nuria Esturau-Escofet and V{\'a}zquez-Landaverde, {Pedro A.} and Alejandra Rojas-Molina",
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Delgado-Altamirano, R, López-Palma, RI, Monzote, L, Delgado-Domínguez, J, Becker, I, Rivero-Cruz, JF, Esturau-Escofet, N, Vázquez-Landaverde, PA & Rojas-Molina, A 2019, 'Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico', International journal of molecular sciences, vol. 20, n.º 4, 872. https://doi.org/10.3390/ijms20040872

Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico. / Delgado-Altamirano, Ronna; López-Palma, Rosa Isela; Monzote, Lianet; Delgado-Domínguez, José; Becker, Ingeborg; Rivero-Cruz, José Fausto; Esturau-Escofet, Nuria; Vázquez-Landaverde, Pedro A.; Rojas-Molina, Alejandra.

En: International journal of molecular sciences, Vol. 20, N.º 4, 872, 02.02.2019.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Chemical constituents with leishmanicidal activity from a pink-yellow cultivar of Lantana camara var. aculeata (L.) collected in Central Mexico

AU - Delgado-Altamirano, Ronna

AU - López-Palma, Rosa Isela

AU - Monzote, Lianet

AU - Delgado-Domínguez, José

AU - Becker, Ingeborg

AU - Rivero-Cruz, José Fausto

AU - Esturau-Escofet, Nuria

AU - Vázquez-Landaverde, Pedro A.

AU - Rojas-Molina, Alejandra

PY - 2019/2/2

Y1 - 2019/2/2

N2 - Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC 50 ) = 12.02 ± 0.36 µM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

AB - Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), β-ionone (3), caryophyllene oxide (4), β-caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC 50 ) = 12.02 ± 0.36 µM). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

KW - Bio-directed fractionation

KW - Camaric acid

KW - Lantadene b

KW - Lantana camara

KW - Lantanilic acid

KW - Leishmania amazonensis

KW - Leishmania mexicana

KW - Leishmanicidal activity

KW - Triterpenes

UR - http://www.scopus.com/inward/record.url?scp=85061863537&partnerID=8YFLogxK

U2 - 10.3390/ijms20040872

DO - 10.3390/ijms20040872

M3 - Artículo

C2 - 30781602

AN - SCOPUS:85061863537

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 4

M1 - 872

ER -