Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins

Miriam A. Anaya-Loyola, José A. Enciso-Moreno, Juan E. López-Ramos, Gabriela García-Marín, María Y. Orozco Álvarez, A. M. Vega-García, Juan Mosqueda, David G. García-Gutiérrez, D. Keller, I. F. Pérez-Ramírez

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC30®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6–8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.

Idioma originalInglés
Número de artículo108567
PublicaciónFood Research International
Volumen125
DOI
EstadoPublicada - nov 2019

Huella dactilar

Bacillus coagulans
Upper Gastrointestinal Tract
respiratory system
Respiratory Tract Infections
Respiratory System
respiratory tract diseases
signs and symptoms (animals and humans)
gastrointestinal system
Nose
Hoarseness
Probiotics
probiotics
placebos
Gastrointestinal Tract
Proteins
proteins
Asthenopia
Placebos
flatulence
Flatulence

Citar esto

Anaya-Loyola, M. A., Enciso-Moreno, J. A., López-Ramos, J. E., García-Marín, G., Orozco Álvarez, M. Y., Vega-García, A. M., ... Pérez-Ramírez, I. F. (2019). Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins. Food Research International, 125, [108567]. https://doi.org/10.1016/j.foodres.2019.108567
Anaya-Loyola, Miriam A. ; Enciso-Moreno, José A. ; López-Ramos, Juan E. ; García-Marín, Gabriela ; Orozco Álvarez, María Y. ; Vega-García, A. M. ; Mosqueda, Juan ; García-Gutiérrez, David G. ; Keller, D. ; Pérez-Ramírez, I. F. / Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins. En: Food Research International. 2019 ; Vol. 125.
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title = "Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins",
abstract = "This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086{\circledR} probiotic (GanedenBC30{\circledR}) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6–8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.",
keywords = "Bacillus coagulans GBI-30, GanedenBC{\circledR}, Gastrointestinal, Immune system, Probiotic, Upper respiratory",
author = "Anaya-Loyola, {Miriam A.} and Enciso-Moreno, {Jos{\'e} A.} and L{\'o}pez-Ramos, {Juan E.} and Gabriela Garc{\'i}a-Mar{\'i}n and {Orozco {\'A}lvarez}, {Mar{\'i}a Y.} and Vega-Garc{\'i}a, {A. M.} and Juan Mosqueda and Garc{\'i}a-Guti{\'e}rrez, {David G.} and D. Keller and P{\'e}rez-Ram{\'i}rez, {I. F.}",
year = "2019",
month = "11",
doi = "10.1016/j.foodres.2019.108567",
language = "Ingl{\'e}s",
volume = "125",
journal = "Food Research International",
issn = "0963-9969",
publisher = "Elsevier Ltd",

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Anaya-Loyola, MA, Enciso-Moreno, JA, López-Ramos, JE, García-Marín, G, Orozco Álvarez, MY, Vega-García, AM, Mosqueda, J, García-Gutiérrez, DG, Keller, D & Pérez-Ramírez, IF 2019, 'Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins', Food Research International, vol. 125, 108567. https://doi.org/10.1016/j.foodres.2019.108567

Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins. / Anaya-Loyola, Miriam A.; Enciso-Moreno, José A.; López-Ramos, Juan E.; García-Marín, Gabriela; Orozco Álvarez, María Y.; Vega-García, A. M.; Mosqueda, Juan; García-Gutiérrez, David G.; Keller, D.; Pérez-Ramírez, I. F.

En: Food Research International, Vol. 125, 108567, 11.2019.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Bacillus coagulans GBI-30, 6068 decreases upper respiratory and gastrointestinal tract symptoms in healthy Mexican scholar-aged children by modulating immune-related proteins

AU - Anaya-Loyola, Miriam A.

AU - Enciso-Moreno, José A.

AU - López-Ramos, Juan E.

AU - García-Marín, Gabriela

AU - Orozco Álvarez, María Y.

AU - Vega-García, A. M.

AU - Mosqueda, Juan

AU - García-Gutiérrez, David G.

AU - Keller, D.

AU - Pérez-Ramírez, I. F.

PY - 2019/11

Y1 - 2019/11

N2 - This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC30®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6–8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.

AB - This randomized, double-blind, parallel and placebo-controlled study aimed to evaluate the effect of Bacillus coagulans GBI-30, 6086® probiotic (GanedenBC30®) against upper respiratory tract infections (URTI) and gastrointestinal tract infections (GITI) in eighty healthy school-aged children (6–8 years old). The participants received daily a sachet containing either GanedenBC30 (1 × 109 colony-forming units) or placebo (maltodextrin) for three months. GanedenBC30 significantly decreased the incidence of URTI symptoms including nasal congestion, bloody nasal mucus, itchy nose, and hoarseness. The duration of the URTI-associated symptoms of hoarseness, headache, red eyes, and fatigue was also decreased. GanedenBC30 supplementation also significantly reduced the incidence rate of flatulence. These beneficial effects were associated with the modulation of serum TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP-2, RAGE, uPAR, and PF4. Therefore, probiotic B. coagulans GBI-30, 6086 modulated immune-related proteins in healthy children, decreasing several URTI and GITI symptoms, thus, this functional ingredient may contribute to a healthier lifestyle.

KW - Bacillus coagulans GBI-30

KW - GanedenBC®

KW - Gastrointestinal

KW - Immune system

KW - Probiotic

KW - Upper respiratory

UR - http://www.scopus.com/inward/record.url?scp=85069833567&partnerID=8YFLogxK

U2 - 10.1016/j.foodres.2019.108567

DO - 10.1016/j.foodres.2019.108567

M3 - Artículo

AN - SCOPUS:85069833567

VL - 125

JO - Food Research International

JF - Food Research International

SN - 0963-9969

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ER -