Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children

Yun Liu, Martha Téllez-Rojo, Brisa N. Sánchez, Adrienne S. Ettinger, Citlalli Osorio-Yáñez, Maritsa Solano, Howard Hu, Karen E. Peterson

Resultado de la investigación: Contribución a una revistaArtículo

Resumen

Background: Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans. Objectives: We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10–18 years living in Mexico City. Methods: We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations. Results: The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21 μmol/L (0.20, 0.23 μmol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: β = 1.28, 95% CI: 0.57–2.00, p-sex interaction = 0.02)), adjusting for covariates. No associations were found in boys. Conclusions: We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.

Idioma originalInglés
Número de artículo105302
PublicaciónEnvironment International
Volumen134
DOI
EstadoPublicada - ene 2020

Huella dactilar

fluoride
risk factor
plasma
confidence interval
lipid
fasting
exposure
fat
serum
glucose
animal
marker

Citar esto

Liu, Y., Téllez-Rojo, M., Sánchez, B. N., Ettinger, A. S., Osorio-Yáñez, C., Solano, M., ... Peterson, K. E. (2020). Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children. Environment International, 134, [105302]. https://doi.org/10.1016/j.envint.2019.105302
Liu, Yun ; Téllez-Rojo, Martha ; Sánchez, Brisa N. ; Ettinger, Adrienne S. ; Osorio-Yáñez, Citlalli ; Solano, Maritsa ; Hu, Howard ; Peterson, Karen E. / Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children. En: Environment International. 2020 ; Vol. 134.
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title = "Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children",
abstract = "Background: Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans. Objectives: We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10–18 years living in Mexico City. Methods: We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations. Results: The geometric mean (95{\%} confidence interval (CI)) of plasma fluoride was 0.21 μmol/L (0.20, 0.23 μmol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: β = 1.28, 95{\%} CI: 0.57–2.00, p-sex interaction = 0.02)), adjusting for covariates. No associations were found in boys. Conclusions: We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.",
keywords = "Adiposity, Blood pressure, Cardiometabolic risk, Insulin resistance, Plasma fluoride",
author = "Yun Liu and Martha T{\'e}llez-Rojo and S{\'a}nchez, {Brisa N.} and Ettinger, {Adrienne S.} and Citlalli Osorio-Y{\'a}{\~n}ez and Maritsa Solano and Howard Hu and Peterson, {Karen E.}",
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language = "Ingl{\'e}s",
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Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children. / Liu, Yun; Téllez-Rojo, Martha; Sánchez, Brisa N.; Ettinger, Adrienne S.; Osorio-Yáñez, Citlalli; Solano, Maritsa; Hu, Howard; Peterson, Karen E.

En: Environment International, Vol. 134, 105302, 01.2020.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Association between fluoride exposure and cardiometabolic risk in peripubertal Mexican children

AU - Liu, Yun

AU - Téllez-Rojo, Martha

AU - Sánchez, Brisa N.

AU - Ettinger, Adrienne S.

AU - Osorio-Yáñez, Citlalli

AU - Solano, Maritsa

AU - Hu, Howard

AU - Peterson, Karen E.

PY - 2020/1

Y1 - 2020/1

N2 - Background: Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans. Objectives: We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10–18 years living in Mexico City. Methods: We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations. Results: The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21 μmol/L (0.20, 0.23 μmol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: β = 1.28, 95% CI: 0.57–2.00, p-sex interaction = 0.02)), adjusting for covariates. No associations were found in boys. Conclusions: We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.

AB - Background: Several animal studies have suggested that fluoride exposure may increase the levels of cardiometabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans. Objectives: We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10–18 years living in Mexico City. Methods: We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations. Results: The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21 μmol/L (0.20, 0.23 μmol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: β = 1.28, 95% CI: 0.57–2.00, p-sex interaction = 0.02)), adjusting for covariates. No associations were found in boys. Conclusions: We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.

KW - Adiposity

KW - Blood pressure

KW - Cardiometabolic risk

KW - Insulin resistance

KW - Plasma fluoride

UR - http://www.scopus.com/inward/record.url?scp=85074572705&partnerID=8YFLogxK

U2 - 10.1016/j.envint.2019.105302

DO - 10.1016/j.envint.2019.105302

M3 - Artículo

AN - SCOPUS:85074572705

VL - 134

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 105302

ER -