Anti-inflammatory activity of aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae)

Carlos L. Céspedes, Julio Alarcon, Jose Guillermo Avila Acevedo, Antonio Nieto

Resultado de la investigación: Contribución a una revistaArtículo

30 Citas (Scopus)

Resumen

Context: "Chilean Black-berry" Aristotelia chilensis is a wild fruit that growth in southern Chile. This fruit possess a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The anti-inflammatory activity of the extracts, fractions and subfractions of this fruit are investigated here for the first time. Materials and methods: Extracts, fractions and subfractions were analyzed for their content in total phenolics and the effects in the TPA-induced inflammation in ear of the mouse ear edema induced by single doses of TPA were investigated. In addition, the antioxidant activity was investigated against DPPH, Crocin and TBARS. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in phenolic compounds. Thus, SF11- SF15, SF16-SF20, and SF21-SF25 showed are the best subfractions inhibitors in similar form to indomethacin a known selective COX inhibitor that have an EI50 of 0.11 mg/ear. Results demonstrated that these samples strongly inhibited the induced inflammation in ear of the mouse edema in TPA inflammation model, with EC50 values ranging from 0.3 to 11.8 μg/mL. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis have excellent anti-inflammatory activities and thus have great potential as a source for natural health products. Additionally, these findings showed that the flavonoids, phenolic acids and anthocyanins present in this fruit may be responsible of the antioxidant activity observed.

Idioma originalInglés
Páginas (desde-hasta)127-135
Número de páginas9
PublicaciónBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volumen9
N.º2
EstadoPublicada - 1 mar 2010

Huella dactilar

Elaeocarpaceae
Aristotelia chilensis
anti-inflammatory activity
Fruit
Anti-Inflammatory Agents
ears
fruits
antioxidant activity
inflammation
Otitis
Antioxidants
Chile
edema
extracts
Ear
Edema
myricetin
indomethacin
luteolin
mice

Citar esto

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Anti-inflammatory activity of aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae). / Céspedes, Carlos L.; Alarcon, Julio; Avila Acevedo, Jose Guillermo; Nieto, Antonio.

En: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, Vol. 9, N.º 2, 01.03.2010, p. 127-135.

Resultado de la investigación: Contribución a una revistaArtículo

TY - JOUR

T1 - Anti-inflammatory activity of aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae)

AU - Céspedes, Carlos L.

AU - Alarcon, Julio

AU - Avila Acevedo, Jose Guillermo

AU - Nieto, Antonio

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Context: "Chilean Black-berry" Aristotelia chilensis is a wild fruit that growth in southern Chile. This fruit possess a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The anti-inflammatory activity of the extracts, fractions and subfractions of this fruit are investigated here for the first time. Materials and methods: Extracts, fractions and subfractions were analyzed for their content in total phenolics and the effects in the TPA-induced inflammation in ear of the mouse ear edema induced by single doses of TPA were investigated. In addition, the antioxidant activity was investigated against DPPH, Crocin and TBARS. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in phenolic compounds. Thus, SF11- SF15, SF16-SF20, and SF21-SF25 showed are the best subfractions inhibitors in similar form to indomethacin a known selective COX inhibitor that have an EI50 of 0.11 mg/ear. Results demonstrated that these samples strongly inhibited the induced inflammation in ear of the mouse edema in TPA inflammation model, with EC50 values ranging from 0.3 to 11.8 μg/mL. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis have excellent anti-inflammatory activities and thus have great potential as a source for natural health products. Additionally, these findings showed that the flavonoids, phenolic acids and anthocyanins present in this fruit may be responsible of the antioxidant activity observed.

AB - Context: "Chilean Black-berry" Aristotelia chilensis is a wild fruit that growth in southern Chile. This fruit possess a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The anti-inflammatory activity of the extracts, fractions and subfractions of this fruit are investigated here for the first time. Materials and methods: Extracts, fractions and subfractions were analyzed for their content in total phenolics and the effects in the TPA-induced inflammation in ear of the mouse ear edema induced by single doses of TPA were investigated. In addition, the antioxidant activity was investigated against DPPH, Crocin and TBARS. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in phenolic compounds. Thus, SF11- SF15, SF16-SF20, and SF21-SF25 showed are the best subfractions inhibitors in similar form to indomethacin a known selective COX inhibitor that have an EI50 of 0.11 mg/ear. Results demonstrated that these samples strongly inhibited the induced inflammation in ear of the mouse edema in TPA inflammation model, with EC50 values ranging from 0.3 to 11.8 μg/mL. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis have excellent anti-inflammatory activities and thus have great potential as a source for natural health products. Additionally, these findings showed that the flavonoids, phenolic acids and anthocyanins present in this fruit may be responsible of the antioxidant activity observed.

KW - Anti-inflammatory activity

KW - Antioxidants

KW - Aristotelia chilensis

KW - Crocin

KW - DPPH

KW - TBARS

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M3 - Artículo

AN - SCOPUS:77953868777

VL - 9

SP - 127

EP - 135

JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

SN - 0717-7917

IS - 2

ER -