Activation of D1 receptors stimulates accumulation of γ-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats

Jorge Aceves, Benjamin Floran, Daniel Martinez-Fong, Joaquin Benitez, Arturo Sierra, Gonzalo Flores Alvarez

Resultado de la investigación: Contribución a una revistaArtículo

30 Citas (Scopus)

Resumen

D1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. Here we have studied the effect of the activation of these receptors on the synthesis of γ-aminobutyric acid (GABA) in slices of the pars reticulata of the substantia nig isolated from 6-hydroxydopamine-lesioned rats. The synthesis was judged by the accumulation of GABA after inhibiting GABA transaminase with aminooxyacetic acid. Both dopamine and SCH 23390, a D1 agonist, stimulated the synthesis. The effect of both compounds was blocked by SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. In the absence of receptor activation, the synthesis was very slow. The results a trophic influence of dopamine upon the synthesis of GABA via D1 receptors.

Idioma originalInglés
Páginas (desde-hasta)40-42
Número de páginas3
PublicaciónNeuroscience Letters
Volumen145
N.º1
DOI
EstadoPublicada - 28 sep 1992

Huella dactilar

Aminobutyrates
Oxidopamine
gamma-Aminobutyric Acid
Dopamine
Aminooxyacetic Acid
4-Aminobutyrate Transaminase
Corpus Striatum
Dopamine D1 Receptors
Sulpiride
Neurons
Pars Reticulata
SCH 23390

Citar esto

Aceves, Jorge ; Floran, Benjamin ; Martinez-Fong, Daniel ; Benitez, Joaquin ; Sierra, Arturo ; Flores Alvarez, Gonzalo. / Activation of D1 receptors stimulates accumulation of γ-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats. En: Neuroscience Letters. 1992 ; Vol. 145, N.º 1. pp. 40-42.
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abstract = "D1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. Here we have studied the effect of the activation of these receptors on the synthesis of γ-aminobutyric acid (GABA) in slices of the pars reticulata of the substantia nig isolated from 6-hydroxydopamine-lesioned rats. The synthesis was judged by the accumulation of GABA after inhibiting GABA transaminase with aminooxyacetic acid. Both dopamine and SCH 23390, a D1 agonist, stimulated the synthesis. The effect of both compounds was blocked by SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. In the absence of receptor activation, the synthesis was very slow. The results a trophic influence of dopamine upon the synthesis of GABA via D1 receptors.",
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Activation of D1 receptors stimulates accumulation of γ-aminobutyric acid in slices of the pars reticulata of 6-hydroxydopamine-lesioned rats. / Aceves, Jorge; Floran, Benjamin; Martinez-Fong, Daniel; Benitez, Joaquin; Sierra, Arturo; Flores Alvarez, Gonzalo.

En: Neuroscience Letters, Vol. 145, N.º 1, 28.09.1992, p. 40-42.

Resultado de la investigación: Contribución a una revistaArtículo

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AU - Aceves, Jorge

AU - Floran, Benjamin

AU - Martinez-Fong, Daniel

AU - Benitez, Joaquin

AU - Sierra, Arturo

AU - Flores Alvarez, Gonzalo

PY - 1992/9/28

Y1 - 1992/9/28

N2 - D1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. Here we have studied the effect of the activation of these receptors on the synthesis of γ-aminobutyric acid (GABA) in slices of the pars reticulata of the substantia nig isolated from 6-hydroxydopamine-lesioned rats. The synthesis was judged by the accumulation of GABA after inhibiting GABA transaminase with aminooxyacetic acid. Both dopamine and SCH 23390, a D1 agonist, stimulated the synthesis. The effect of both compounds was blocked by SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. In the absence of receptor activation, the synthesis was very slow. The results a trophic influence of dopamine upon the synthesis of GABA via D1 receptors.

AB - D1 dopamine receptors are present on terminals of striatal neurons to the pars reticulata of the substantia nigra in the rat. Here we have studied the effect of the activation of these receptors on the synthesis of γ-aminobutyric acid (GABA) in slices of the pars reticulata of the substantia nig isolated from 6-hydroxydopamine-lesioned rats. The synthesis was judged by the accumulation of GABA after inhibiting GABA transaminase with aminooxyacetic acid. Both dopamine and SCH 23390, a D1 agonist, stimulated the synthesis. The effect of both compounds was blocked by SCH 23390, a D1 antagonist, but not by sulpiride, a D2 antagonist. In the absence of receptor activation, the synthesis was very slow. The results a trophic influence of dopamine upon the synthesis of GABA via D1 receptors.

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KW - Glutamic acid decarboxylase

KW - Striatonigral projection

KW - Substantia nigra

KW - γ-Aminobutyric acid synthesis

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